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. 2022 Feb 21;13:849922. doi: 10.3389/fimmu.2022.849922

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Copyright © 2022 Lagumdzic, Pernold, Viano, Olgiati, Schmitt, Mair and Saalmüller

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcription profiles of naïve, intermediate and terminally differentiated CD8⁺ T-cell subsets. Data derived from 18 ConA and 18 PMA/ionomycin-stimulated CD8⁺ T-cell subsetsof six animals. As criteria to define DEGs, fold-change > |2| compared to medium control, maximum of the average RPKM’s > 2 and a false discovery rate corrected p-value < 0.01 (FDR) were used. (A) Expression of cytokine genes as log2 fold-change between ConA- and PMA/ionomycin-stimulated CD8⁺ T-cell subsets and their unstimulated control. (B) Expression of chemokine and metabolic genes as log2 fold-change between ConA- and PMA/ionomycin-stimulated CD8⁺ T-cell subsets and their unstimulated control.