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. 2022 Feb 21;13:819680. doi: 10.3389/fimmu.2022.819680

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Copyright © 2022 Sun, Wei, Zhang, Li, Li, Yan, Guo, Han and Qiao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Screening differentially expressed exosome miRNAs. (A) Transmission electron microscopy of plasma exosomes of the SI and NSI groups. (B) Western blot detected exosome-labeled proteins CD9, CD81, and TSG101. (C) Heat map of the cluster analysis of differentially expressed miRNAs among 6 random samples from the SI and NSI groups. (D) Volcano map of differentially expressed miRNAs among 6 random samples from the SI and NSI groups. (E) Scatter plot of KEGG enrichment in differential exosome miRNA target genes. (F) Bar chart of Go enrichment analysis of differential exosome miRNA target genes. (G) Veen analysis of differential exosome miRNA target genes. (H) PCR results of candidate exosome miRNAs among the remaining samples.