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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Gastroenterology. 2021 May 15;161(3):968–981.e12. doi: 10.1053/j.gastro.2021.05.008

Figure 6.

Figure 6.

Exosomes and insulin action. (A and B) Insulin-stimulated phosphorylation of serine 473 of Akt in human skeletal muscle myotubes (A) and mouse hepatocytes (B) treated with exosomes isolated from plasma from LEAN, OB-NL and OB-NAFLD participants and SAAT explants from OB-NL and OB-NAFLD participants. (C) Relationship between skeletal muscle insulin sensitivity (glucose Rd/I) and phosphorylation of serine 473 of Akt in myotubes treated with exosomes isolated from plasma and SAAT in LEAN (black circles), OB-NL (grey circles) and OB-NAFLD (white circles) participants. (D) Relationship between the hepatic insulin sensitivity index and phosphorylation of serine 473 of Akt in hepatocytes treated with exosomes isolated from plasma and SAAT in LEAN (black circles), OB-NL (grey circles) and OB-NAFLD (white circles) participants. Values are means ± SEM. *Value significantly different from the LEAN value, P < .05. †Value significantly different from the OB-NL value, P < .05.

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