Table 2.

Findings, Outcomes, and Sequelae For the 11 HIV+ Subjects With Central Nervous System Imaging^a

Patient Number	CNS Lesion Found by MRI	Neurologic Deficit	CD4 Count (%)b	Viral Load (copies/mL)	Therapy at CNS Event	Outcome
1	Circle of Willis ectasia, calcification of basal ganglia	Yes	22 (0)	183 962	DDI	Alive
2	Multiple aneurysms, multiple infarcts	Yes, blurred vision	5 (1)	41 000	DDI, D4T, NVP, SQV, NFV	Died
3	Internal carotid artery aneurysm	Yes; seizures, right hemiparesis	15 (3)	94 304	DDI, D4T, ABC, IDV, NFV	Died
4	Right MCA infarct	Yes	ND	ND	Not on therapy	Alive
5	Left MCA stroke	Yes	12 (3)	ND	DDI, D4T, EFV, RTV, IDV	Died
6	Left occipital/parietal hemorrhage	Yes	178 (3)	358 996	DDI	Died
7	Hyperintensities in putamen and caudate nucleus; HIV vasculopathy	Yes, coma	0 (0)	1 404 148	Not on therapy	Died
8	Aneurysm of left ACA and narrowing of right MCA	Yes	275 (18)	<50	ABC, ZDV, 3TC, TDF, LPV/r	Alive
9	Narrowing of right middle cerebral artery	Yes	144 (12)	<50	Unknown	Alive
10	Fusiform CNS aneurysm	Hemiplegia	ND	ND	DDI, EFV, IDV, RTV	Alive
11	Multiple CNS aneurysms	Yes	ND	ND	D4T, 3TC, IDV	Alive
12	Diffuse CNS aneurysms with ectasia	Yes	34 (6)	179 914	D4T, NVP	Died

Abbreviations: ABC, abacavir; ACA, anterior cerebral artery; CNS, central nervous system; D4T, stavudine; DDI, didanosine; EFV, efavirenz; HIV, human immunodeficiency virus; HIV + , HIV-infected; DV, indinavir; LPV/r, lopinavir/ritonavir; MCA, middle cerebral artery; MRI, magnetic resonance imaging; ND, test not done; NFV, nelfinavir; NVP, nevirapine; RTV, ritonavir; SQV, saquinavir; TDF, tenofovir; ZDV, zidovudine; 3TC, lamivudine.

^aAll subjects had an MRI except Patient 4, who was enrolled 4 years after the CNS event; the mode of imaging is unknown for this patient.

^bCD4 counts shown were performed prior to or within 3 months of the CNS event.