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. Author manuscript; available in PMC: 2022 Oct 14.
Published in final edited form as: J Med Chem. 2021 Sep 17;64(19):14230–14246. doi: 10.1021/acs.jmedchem.1c00517

Figure 1.

Figure 1.

Design of ABT-263-based PROTACs. (A) Structure of DT2216; (B) Co-crystal structure of BCL-XL with ABT-263 (PDB code 4QNQ); (C) General structure of newly explored BCL-2/BCL-XL-targeting PROTACs. Arrows indicate the linking position.