. Author manuscript; available in PMC: 2022 Oct 14.

Published in final edited form as: J Med Chem. 2021 Sep 17;64(19):14230–14246. doi: 10.1021/acs.jmedchem.1c00517

Table 1.

Cell-Killing Potency of PP1-PP8 in MOLT-4 and RS4;11 Cells^a

Compound	MOLT-4	RS4;11	Compound	MOLT-4	RS4;11
ABT-263	212.3 ± 26.0	42.6 ± 5.7	PP6	74.6 ± 14.6	29.2 ± 4.9
DT2216	75.3 ± 9.1	211.7 ± 27.4	PP7	111.8 ± 9.3	96.3 ± 15.3
PP1	340.2 ± 29.4	303.6 ± 32.8	PP8	333.6 ± 25.8	409.8 ± 38.6
PP2	306.8 ± 31.9	234.2 ± 21.6	PZ703a	170.4 ± 19.6	418.3 ± 45.4
PP3	219.4 ± 18.6	108.4 ± 12.9	PZ703b	15.9 ± 2.7	11.3 ± 2.2
PP4	124.7 ± 11.3	43.7 ± 5.1	PZ703b-NC	820.6 ± 112.5	328.0 ± 48.5
PP5	32.1 ± 3.7	23.3 ± 4.0

IC50 values (in nM) are reported as the mean ± standard deviation from three independent experiments performed in triplicates. Cells were treated for 48 h.