Table 4.
Multivariable regression analysis of outcomes in patients treated with auto-HCT or CAR-T while in a PR
| Outcomes | N | HR | 95% CI lower limit | 95% CI lower limit | P value |
|---|---|---|---|---|---|
| Nonrelapse mortality | |||||
| Age, y | |||||
| <60 | 212 | 1.00 | |||
| ≥60 | 182 | 2.92 | 1.31 | 6.50 | .009 |
| Main effect | |||||
| Auto-HCT | 256 | 1.00 | |||
| CAR-T | 138 | 0.49 | 0.18 | 1.32 | .16 |
| Progression/relapse | |||||
| Main effect | |||||
| Auto-HCT | 256 | 1.00 | |||
| CAR-T | 138 | 1.49 | 1.08 | 2.05 | .01 |
| Progression-free survival | |||||
| Main effect | |||||
| Auto-HCT | 256 | 1.00 | |||
| CAR-T | 138 | 1.33 | 0.98 | 1.80 | .06 |
| Overall survival | |||||
| Main effect | |||||
| Auto-HCT | 266 | 1.00 | |||
| CAR-T | 145 | 1.63 | 1.14 | 2.33 | .008 |
Variables included in the multivariable analysis: age (continuous by decade), Karnofsky performance score (≥90 vs <90 vs missing), refractoriness to first line, lines of prior treatment, interval between diagnosis and auto-HCT or CAR-T (≥1 y vs <1 y vs missing), largest node at auto-HCT or CAR-T (<3 cm vs 3-5 cm vs >5 cm vs unknown).