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. 2022 Mar 7;20:116. doi: 10.1186/s12967-022-03317-7

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© The Author(s) 2022, corrected publication 2024

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Lenvatinib treatment reduced blood vessel density and increased apoptosis in PDX tumors. A H&E and CD31 IHC of vehicle and lenvatinib-treated PDXs (200× magnification) B Intratumoral vascular density quantification. Each dot represents one tumor. The error bar represents the standard error of the mean. C Ki-67 staining of vehicle and lenvatinib-treated tumors. D Ki-67 quantification of vehicle and lenvatinib-treated tumors. Each dot represents the average Ki-67 percentage per PDX line. The error bar represents the standard error of the mean. E TUNEL immunofluorescence staining of vehicle and lenvatinib-treated tumors. F Quantification of TUNEL-positive cells. Each dot represents the average TUNEL-positive cells per PDX line. The error bar represents the standard error of the mean