Table 2.
Patient demographic, clinical, and pathologic factors associated with PDX engraftment
| Variable | n (%) | P value | |
|---|---|---|---|
| Engrafted (n = 23) | Not engrafted (n = 116) | ||
| Gender | |||
| Male | 19 (83) | 72 (62) | NS |
| Female | 4 (17) | 44 (38) | |
| Race/ethnicity | |||
| Non-Hispanic White | 3 (13) | 27 (23) | < 0.05 |
| Black/African American | 10 (43) | 16 (14) | |
| Hispanic | 9 (39) | 68 (59) | |
| Asian | 1 (4) | 4 (3) | |
| American Indian | 0 (0) | 1 (1) | |
| Presenting stage | |||
| Local | 0 (0) | 2 (2) | NS |
| Locally advanced | 13 (57) | 65 (56) | |
| Metastatic | 10 (43) | 49 (42) | |
| Lauren classification | |||
| Intestinal | 14 (61) | 33 (35) | < 0.01 |
| Diffuse | 3 (13) | 51 (54) | |
| Mixed | 6 (26) | 11 (12) | |
| Unknown | 0 | 21 | |
| Differentiation | |||
| Well | 0 (0) | 1 (1) | NS |
| Moderate | 7 (30) | 24 (22) | |
| Poor | 16 (70) | 86 (77) | |
| Unknown | 0 | 5 | |
| H. pylori infection | |||
| Negative | 15 (79) | 67 (72) | NS |
| Positive | 4 (21) | 26 (28) | |
| Unknown | 4 | 23 | |
| HER2 status | |||
| 0–1+ or 2+ NAmp | 12 (75) | 60 (78) | NS |
| 3+ or 2+ Amp | 4 (25) | 17 (22) | |
| Unknown | 7 | 39 | |
| Tissue sourcea | |||
| EGD biopsy | 9 (39) | 96 (54) | NS |
| Resection | 8 (35) | 56 (32) | |
| Metastasis biopsy | 6 (26) | 25 (14) | |
A HER2 score of 3+ or 2+ and fluorescent in situ hybridization (FISH) amplified was considered positive. A HER2 score of 0–1+ or 2+ and FISH non-amplified was considered negative
Amp, fluorescence in situ hybridization (FISH) amplified; EGD, esophagogastroduodenoscopy; NAmp, FISH non-amplified
aMultiple samples were collected from some patients