Table 1.
Variants associated with increased risk for non-medullary thyroid cancer in various populations identified by GWAS
| Genes | Chr. | Reference | variant | Population | Type of tumoura | OR | P value |
|---|---|---|---|---|---|---|---|
| MBIP | 14q13.3 | Gudmundsson et al. (2012) [27] | rs116909374 | Iceland | NMTC | 2.09 | 4.6 × 10−11 |
| Gudmundsson et al. (2017) [28] | rs116909374 | European ancestry | NMTC | 1.81 | 1.1 × 10− 16 | ||
| Son et al. (2017) [29] | rs34081947 | Korean | PTC | 1.28 | 2.4 × 10− 4 | ||
| Son et al. (2017) [29] | rs944289 | Korean | PTC | 1.24 | 1.41 × 10− 3 | ||
| PCNLX2 | 1q42.2 | Gudmundsson et al. (2017) [28] | rs12129938 | Iceland, Spain, United States, Netherlands | NMTC | 1.32 | 4.0 × 10− 11 |
| LRRC34, TERC | 3q26.2 | Gudmundsson et al. (2017) [28] | rs6793295 | Iceland, Spain, United States, Netherlands | NMTC | 1.23 | 2.7 × 10− 8 |
| TERT | 5p15.33 | Gudmundsson et al. (2017) [28] | rs10069690 | Iceland, Spain, United States, Netherlands | NMTC | 1.20 | 3.2 × 10− 7 |
| EPB41L4A, NREP | 5q22.1 | Gudmundsson et al. (2017) [28] | rs73227498 | Iceland, Spain, United States, Netherlands | NMTC | 1.37 | 3.0 × 10− 10 |
| OBFC1 | 10q24.33 | Gudmundsson et al. (2017) [28] | rs7902587 | Iceland, Spain, United States, Netherlands | NMTC | 1.41 | 5.4 × 10− 11 |
| SMAD3 | 15q22.33 | Gudmundsson et al. (2017) [28] | rs2289261 | Iceland, Spain, United States, Netherlands | NMTC | 1.23 | 3.1 × 10− 9 |
| IMMP2L | 7q31.1 | Köhler et al. (2013) [30] | rs10238549 | Italy | DTC | 1.27 | 4.1 × 10− 6 |
| Köhler et al. (2013) [30] | rs7800391 | Italy | DTC | 1.25 | 5.7 × 10− 6 | ||
| RARRES1 | 3q25.32 | Köhler et al. (2013) [30] | rs7617304 | Italy | DTC | 1.25 | 4.6 × 10− 5 |
| SNAPC4 | 9q34.3 | Köhler et al. (2013) [30] | rs10781500 | Italy | DTC | 1.23 | 3.5 × 10− 5 |
| PLAU | 10q22.2 | Köhler et al. (2013) [30] | rs2633322 | Italy | DTC | 1.21 | 5.3 × 10− 3 |
| SNX19 | 11q24.3-q25 | Köhler et al. (2013) [30] | rs11823005 | Italy | DTC | 1.35 | 1.7 × 10− 3 |
| GTSCR1 | 18q22.2 | Köhler et al. (2013) [30] | rs9951245 | Italy | DTC | 1.20 | 9.8 × 10− 4 |
| BATF | 14q24.3 | Figlioli et al. (2014) [31] | rs10136427 | Italy | DTC | 1.40 | 4.4 × 10− 7 |
| DHX35 | 20q11.23-q12 | Figlioli et al. (2014) [31] | rs7267944 | Italy | DTC | 1.39 | 2.1 × 10− 8 |
| ARSB | 5q14.1 | Figlioli et al. (2014) [31] | rs13184587 | Italy | DTC | 1.28 | 8.5 × 10− 6 |
| SPATA13 | 13q12.12 | Figlioli et al. (2014) [31] | rs1220597 | Italy | DTC | 1.26 | 3.3 × 10− 6 |
| GPD1L | 3p22.3 | Figlioli et al. (2014) [31] | rs1159444 | Italian, Polish, Spanish | DTC | 1.23 | 9.13 × 10− 4 |
| TIPRL | 1q24.2 | Figlioli et al. (2014) [31] | rs2281016 | Italian, Polish, Spanish | DTC | 1.16 | 2.0 × 10− 3 |
| DACH1 | 13q21.33 | Figlioli et al. (2014) [31] | rs2245026 | Italian, Polish, Spanish | DTC | 1.17 | 2.0 × 10− 3 |
| GALNTL4 | 11p15.4 | Figlioli et al. (2015) [32] | rs7935113 | Italian | DTC | 1.36 | 7.4 × 10− 7 |
| FOXA2 | 20p11.21 | Figlioli et al. (2015) [32] | rs1203952 | Italian | DTC | 1.29 | 4.4 × 10− 6 |
| CAMTA1 | 1p36.31-p36.23 | Figlioli et al. (2015) [32] | rs10864251 | Italian | DTC | 1.17 | 1.40 × 10− 3 |
| Figlioli et al. (2015) [32] | rs4908581 | Italian | DTC | 1.22 | 4.61 × 10− 5 | ||
| LOC728241 | 2 | Figlioli et al. (2015) [32] | rs1400967 | Italian | DTC | 1.22 | 7.11 × 10− 4 |
| C3orf63 | 3p14.3 | Figlioli et al. (2015) [32] | rs11130536 | Italian | DTC | 1.24 | 3.27 × 10− 4 |
| PDZRN3 | 3p13 | Figlioli et al. (2015) [32] | rs3863973 | Italian | DTC | 1.22 | 5.95 × 10− 4 |
| SYK | 9q22.2 | Figlioli et al. (2015) [32] | rs290212 | Italian | DTC | 1.23 | 6.84 × 10− 5 |
| C14orf147 | 14q13.1 | Figlioli et al. (2015) [32] | rs4624074 | Italian | DTC | 1.20 | 1.46 × 10− 4 |
| WDR11-AS1 | 10q26.12 | Mancikova et al. (2015) [33] | rs2997312 | Southern European | NMTC | 1.35 | 1.2 × 10− 4 |
| Mancikova et al. (2015) [33] | rs10788123 | Southern European | NMTC | 1.26 | 5.2 × 10− 4 | ||
| Mancikova et al. (2015) [33] | rs1254167 | Southern Europea | NMTC | 1.38 | 5.9 × 10− 5 | ||
| HTR1B | 6q14.1 | Mancikova et al. (2015) [33] | rs4075570 | Southern European | NMTC | 0.82 | 2.0 × 10− 4 |
| PCNXL2 | 1q42.2 | Son et al. (2017) [29] | rs4649295 | Korean | PTC | 1.45 | 8.53 × 10− 8 |
| VAV3 | 1p13.3 | Son et al. (2017) [29] | rs4915076 | Korean | PTC | 1.34 | 7.09 × 10− 8 |
| MSRB3 | 12q14.3 | Son et al. (2017) [29] | rs11175834 | Korean | PTC | 1.36 | 4.86 × 10− 7 |
| SEPT11 | 4q21.1 | Son et al. (2017) [29] | rs1874564 | Korean | PTC | 1.31 | 5.87 × 10− 7 |
| FHIT | 3p14.2 | Son et al. (2017) [29] | rs9858271 | Korean | PTC | 1.30 | 2.76 × 10− 8 |
| INSR | 19p13.2 | Son et al. (2017) [29] | rs7248104 | Korean | PTC | 1.23 | 1.64 × 10− 5 |
| SLC24A6 (SLC8B1) | 12q24.13 | Son et al. (2017) [29] | rs16934253 | Korean | PTC | 1.36 | 0.0216 |
aNon-Medullary Thyroid Cancer (NMTC), Papillary Thyroid Cancer (PTC), Differentiated Thyroid Cancer (DTC)