Table 5.

NRG1 variants associated with hereditary thyroid cancer

NRG1 variant	Annotation	Odds ratio	P-value	Type of thyroid cancer	population	Reference
rs2439302	Intron variant	1.36	2.0 × 10− 9	NMTC	Icelandic	Gudmundsson et al. (2012) [27]
		1.41	2.78 × 10− 5	PTC	Chinese	Wang et al. (2013) [67]
		1.27	0.003	PTC	Japanese	Rogounovitch et al. (2015) [63]
		1.46	4.0 × 10− 5	PTC	Kazakh	Mussazhanova et al. (2020) [168]
		1.59	2.45 × 10− 5	PTC	Ohio	Liyanarachchi et al. (2013) [70]
		1.23	9.29 × 10− 4	PTC	Poland	Liyanarachchi et al. (2013) [70]
rs2466076	Intron variant	1.32	1.5 × 10− 17	NMTC	Icelandic	Gudmundsson et al. (2017) [28]
rs6996585	Intron variant	1.43	9.0 × 10− 12	PTC	Korean	Son et al. (2017) [29]
rs12542743	Intron variant	1.39	1.01 × 10− 10	PTC	Korean	Son et al. (2017) [29]
rs2439304	Promoter variant	1.2	0.001	DTC	Europeans, Melanesians and Polynesians	Guibon et al. (2021) [74]