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. 2022 Mar 7;15:9. doi: 10.1186/s13072-022-00441-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — key genes associated with CpG sites, considered as age accelerators/ decelerators. A Blue bars present the percentage of individuals from the "epigenetically old" group which moved to the Avg + 1 SD group after setting consecutive CpG sites (presented with the name of their related gene) to their mean epigenetic age contribution, starting from the CpG site which moved the highest number of individuals to the lowest. B Blue bars are the percentage of individuals from the "epigenetically young" group who moved to the Avg—1 SD after setting consecutive CpG sites to their mean epigenetic age contribution, starting from the site which moved the highest number of individuals to the lowest. The black line is the cumulative percentage of individuals moving from the "epigenetically old (A) /young (B)" group to the average group