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. 2022 Mar 7;15:9. doi: 10.1186/s13072-022-00441-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — The overall relation between epigenetic age and chronological age, including the samples from diabetic subjects. Each blue point represents a single healthy individual. Red dots are the average value of the epigenetic age of the healthy cohort at each chronological age. The diabetic subjects are represented by triangles, superimposed on the general healthy cohort; red triangles are for T1D subjects receiving intensive treatment and are free of complications; black triangles are for T1D subjects receiving conventional therapy who developed microvascular complications (albuminuria and /or retinopathy); and green triangle marks are for T2D. All dots between the orange and the red lines represent individuals with an epigenetic age between the average and average ± 1SD. Dots residing between the orange and the purple lines represent individuals with an epigenetic age between the average ± 1SD and the average ± 2.5 SD