Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 7;12:27. doi: 10.1186/s13578-022-00762-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 3 — Identification of differentially expressed RNAs (DERNAs). Principal component analysis (PCA) of replicates from both hypoxia-induced pulmonary hypertension (HPH) (red) and control (blue) samples. Samples were clustered according to the expression of 500 most variable mRNAs (A), lncRNAs (B), circRNAs (C), and miRNAs (D) in the sequencing dataset. Ellipses represent 95% confidence intervals for the groups. The volcano plot of DEmRNAs (E), DElncRNAs (F), DEcircRNAs (G), and DEmiRNAs (H) between HPH and control samples. Red and blue dots represent downregulated and upregulated DERNAs in HPH rats respectively. The horizontal line represents the value of the padj < 0.05 (E) or p < 0.05 (F–H); the vertical dotted line represents the value of |Log2FoldChange| > 2 (E) or |Log2FoldChange| > 1 (F–H). Expression heatmap of DEmRNAs (I), DElncRNAs (J), DEcircRNAs (K), and DEmiRNAs (L) between HPH and control samples. Unsupervised hierarchical clustering analysis of the DERNAs was performed. Orange color indicates higher expression; blue color indicates lower expression. Nor: normal control rats; Hyp: HPH rats