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Effect of SPIO-clustering on drug loading of PEG-PLA polymeric micelles. (A) Drug loading content (DLC, %) and (B) drug loading efficiency (DLE, %) of SPIO-free and SPIO-loaded micelles (15% Doxo-loading). DLE (%) was calculated using the following equation: [estimated Doxo loading] / [theoretical Doxo loading] × 100. (C) Doxo loading content (%) of SPIO-loaded PEG-PLA micelles with mixing ratio of PEG-PLA and SPIO. Data are expressed as mean ± stdev, *** p < 0.01, ** p < 0.05
