Table 5.
Univariate and multivariate Cox regression analysis for 2-year RFS of HCC patients baseline
| Variables | 2-year recurrence group (N = 112) |
Non-recurrence group (N = 248) |
Univariate | Multivariate | ||
|---|---|---|---|---|---|---|
| P | HR(95% CI) | P | HR(95% CI) | |||
| ALT, U/L (≤50/>50) | 89(79.5%)/23(20.5%) | 198(79.8%)/50(20.2%) | 0.883 | 0.966(0.611-1.528) | 0.002 | 0.437(0.259-0.740) |
| ALBI | – | – | – | |||
| -2.6 | 59(52.7%) | 177(71.4%) | – | – | – | |
| -2.60 - 1.39 | 51(45.5%) | 69(27.8%) | <0.001 | 1.952(1.342-2.841) | – | – |
| >-1.39 | 2(1.8%) | 2(0.8%) | 0.127 | 3.001(0.733-12.292) | – | – |
| AFP,ng/mL | ||||||
| ≤20 | 34(30.4%) | 133(43.6%) | – | – | – | |
| 20-400 | 26(23.2%) | 70(28.2%) | 0.130 | 1.484(0.891-2.474) | 0.240 | 1.361(0.814-2.275) |
| >400 | 52(46.4%) | 45(18.1%) | <0.001 | 2.987(1.938-4.604) | 0.002 | 2.040(1.305-3.191) |
| PNI | 46.7(26.6,65.8) | 49.7(26.5,73.3) | 0.001 | 0.952(0.926-0.979) | – | – |
| APRI | 0.27(0.07,4.58) | 0.20(0.04,2.16) | <0.001 | 2.006(1.421-2.986) | 0.001 | 2.447(1.460-4.102) |
| MVI(yes/no) | 86(76.8%)/26(23.2%) | 94(37.9%)/154(62.1%) | <0.001 | 3.905(2.517-6.060) | <0.001 | 3.027(1.909-4.799) |
| Number of tumors(solitary/multiple) | 80(71.4%)/32(28.6%) | 210(84.7%)/38(15.3%) | 0.003 | 1.858(1.233-2.801) | 0.039 | 1.555(1.022-2.365) |
| Tumor diameter,cm | 6.30±3.45 | 4.39±2.69 | <0.001 | 1.148(1.097-1.202) | 0.001 | 1.095(1.004-1.152) |
| Tumor capsule(yes/no) | 27(24.1%)/85(75.9%) | 34(13.7%)/214(86.3%) | 0.041 | 1.570(1.018-2.421) | – | – |
| PVTT(yes/no) | 21(18.8%)/91(81.3%) | 9(3.6%)/239(96.4%) | <0.001 | 3.666(2.274-5.91) | 0.001 | 2.402(1.453-3.970) |