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. 2022 Mar 7;20:110. doi: 10.1186/s12967-022-03321-x

Table 4.

The result of two-piecewise linear regression model stratified by sex

Incident DM (male) HR (95% CI) P
Fitting model by standard linear regression 1.475 (1.242, 1.753) < 0.001
Fitting model by two-piecewise linear regression
 Inflection point of BRI
  ≤ 3.146 0.903 (0.606, 1.346) 0.617
  > 3.146 1.827 (1.449, 2.303) < 0.001
  P for log likelihood ratio test 0.011
Incident DM (female) HR (95% CI) P
Fitting model by standard linear regression 1.828 (1.386, 2.412) < 0.001
Fitting model by two-piecewise linear regression
 Inflection point of BRI
  ≤ 4.137 1.418 (0.983, 2.045) 0.062
  > 4.137 4.189 (1.862, 9.421) < 0.001
  P for log likelihood ratio test 0.045

We adjusted age, gender, SBP, DBP, smoking status, ethanol consumption, habit of exercise, ALT, AST, GGT, FBG, HbA1c, HDL-c, TC, TG

ALT alanine aminotransferase; AST aspartate aminotransferase; CI confidence interval; DBP diastolic blood pressure; FBG fasting blood glucose; GGT glutamyl transpeptidase; HbA1c hemoglobin A1c; HDL-C high-density lipoprotein cholesterol; HR hazard ratio; Ref reference; SBP systolic blood pressure; TC total cholesterol; TG triglyceride