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. Author manuscript; available in PMC: 2023 Feb 24.
Published in final edited form as: J Med Chem. 2022 Feb 4;65(4):3644–3666. doi: 10.1021/acs.jmedchem.1c02165

Figure 12.

Figure 12.

AKT degrader 20 suppresses the tumor growth in vivo in a PC3 cell line xenograft mouse model. (A) Nude mice (Foxn1nu, athymic nude) bearing established PC-3 xenografts were treated with vehicle (n = 6) or 20 (n = 7, 75 mg/kg, i.p., once daily) for 22 days. Data points represent mean tumor volume ±SE. (B) Body weights of mice at the beginning and the end of the in vivo studies. (C) Western blotting analysis of P-AKT and T-AKT protein levels, and downstream signaling inhibition (P-PRAS40) in the tumor samples isolated from the nude mice treated with vehicle or 20.