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. Author manuscript; available in PMC: 2023 Feb 24.
Published in final edited form as: J Med Chem. 2022 Feb 4;65(4):3644–3666. doi: 10.1021/acs.jmedchem.1c02165

Scheme 3. Syntheses of Negative Control Compounds 42–43a.

Scheme 3.

aReaction conditions: (a) EDCI, HOAt, NMM, DMSO, rt, 12 h; (b) TFA, DCM, rt, 30 min; and (c) N-methyl-2-pyrrolidone (NMP), diisopropylethylamine (DIPEA), MW, 100 °C, 1 h.