Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Effects of compounds 24–41 on reducing the AKT protein level and inhibiting the downstream signaling. BT474 cells were treated with AZD5363 (1 μM), POM (1 μM), or indicated compound at 1, 5, and 10 μM for 24 h. The cell lysates were analyzed by western blotting to examine the protein levels of T-AKT, P-AKT (S473), P-PRAS40 (T246), and P-S6 (S240/244). β-Actin was used as the loading control.
