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Binding affinities of degraders 20 and 35, and negative controls 42 and 43 to AKT1 (A), AKT2 (B), and AKT3 (C). The Kd determination experiments were performed in a competitive binding assay (KINOMEscan assay by Eurofins DiscoverX) in duplicate. The lowest concentration points represent data from the DMSO samples. Error bars represent ± SEM in duplicate independent experiments.
