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AKT degradation induced by compound 20 (A) or compound 35 (B) is mediated through the UPS. PC3 cells were treated with DMSO, AZD5363 (1 μM), MLN4924 (1 μM), MG132 (10 μM), VHL-2 (1 μM), or POM (1 μM) for 2 h, before the cells were treated with 20 or 35 for additional 24 h. The T-AKT and P-PRAS40 protein levels were determined by western blots.
