Table 3.
Genotype frequencies and odds ratios in degree of severity and clinical forms of COVID-19 according to TNFα − 308A > G polymorphism genotypes
| Characteristics | Genotypes | |||||
|---|---|---|---|---|---|---|
| GG (%) | OR (95% CI) | AG (%) | OR (95% CI) | AA (%) | OR (95% CI) | |
| Severity of symptomatic forms of COVID-19 | ||||||
| MS (n = 551) | 430 (78.0) | 0.81 (0.59–1.09) | 110 (20.0) | 1.26 (0.91–1.73) | 11 (2.0) | 1.06 (0.44–2.58) |
| SS (n = 66) | 53 (80.3) | 1.04 (0.56–1.95) | 12 (18.2) | 0.99 (0.52–1.88) | 1 (1.5) | 0.76 (0.10–5.79) |
| Clinical forms | ||||||
| MS&SS (617) | 483 (78.3) | 0.81 (0.59–1.10) | 122 (19.8) | 1.27 (0.91–1.76) | 12 (1.9) | 0.99 (0.41–2.47) |
| AS (n = 411) | 336 (81.8)a | 1.24 (0.91–1.70) | 67 (16.3)a | 0.79 (0.57–1.10) | 8 (1.9) | 1.00 (0.41–2.47) |
Frequencies of TNFa − 308 genotypes are presented in absolute values and percentages
AS asymptomatic, MS mild symptomatic, SS severe symptomatic
aDifferences by the z test when compared with the Cuban reference population