TABLE 2.
Chemokine receptors
| Receptor | Ligands | Expression | Chromosomea |
|---|---|---|---|
| CXC group | |||
| CXCR1 | IL-8, KC, MIP-2 GCP-2 | Neutrophils, monocytes, basophils, mast cells, endothelial cells, T cells, NK cells | 2 (H) |
| CXCR2 | IL-8, GRO-α, NAP-2, ENA-78 | Neutrophils, monocytes, basophils, mast cells, endothelial cells, T cells, NK cells, astrocytes, neurons | 2, 1 (H, M) |
| CXCR3 | IP-10, MIG, I-TAC | Activated Th1 cells | X (H, M) |
| CXCR4 (fusin) | SDF-1α | Myeloid cells, T cells, B cells, epithelial cells, endothelial cells, dendritic cells | 2, 1 (H, M) |
| CXCR5 (BLR1) | BLC/BCA-1 | B cells | 11, 9 (H, M) |
| DARC (Duffy antigen) | IL-8, GRO-α, RANTES, MCP-1, TARC | Erythrocytes, endothelial cells, T cells | 1 (H) |
| CC group | |||
| CCR1 | MIP-1α, RANTES, MCP-3, MPIF-1, HCC-1 | Neutrophils, monocytes, mast cells, T cells, B cells, NK cells, astrocycytes, neurons | 3, 9 (H, M) |
| CCR2a, CCR2b | MCP-1, MCP-3, MCP-4 | Monocytes, T cells, B cells, basophils | 3, 9 (H, M) |
| CCR4 | MDC, TARC | Basophils, NK cells, dendritic cells, Th1 cells, Th2 cells | 3, 9 (H, M) |
| CCR3 | Eotaxin 1–3, RANTES, MCP-3, MCP-4 | Th2 cells, eosinophils, basophils | 3, 9 (H, M) |
| CCR5 | RANTES, MIP-1α, MIP-1β | Monocytes, dendritic cells, Th1 cells, epithelial cells | 3, 9 (H, M) |
| CCR6 | LARC/MIP-3α/Exodus | Lymphocytes, dendritic cells | 6 (H) |
| CCR7 | SLC/6Ckine/Exodus2/TCA4, CKbeta-11/MIP-3beta/ELC | T cells, B cells, monocytes, NK cells, dendritic cells | 17 (H) |
| CCR8 | I309/mTCA3, TARC | Monocytes, Th2 cells, smooth muscle cells, thymocytes | 3 (H) |
| CCR9 | TECK, RANTES MIP-1α, MIP-1β | Thymocytes, dendritic cells, activated macrophages | 3 (H) |
| CCR10 | CTACK/ILC | T cells, fibroblasts, melanocytes, skin Langerhans' cells, placental cells, liver cells | 3 (H) |
| XCR group | |||
| XCR (GPR5) | Lymphotactin | T cells, B cells, NK cells | 3 (H, M) |
| CX3CR group | |||
| CX3CR1 (V28) | Fractalkine | NK cells, monocytes, T cells | 3 (H) |
a
H, human; M, mouse.