Table 1.
Summary of recommended follow-up interval and mFOCUS eligibility window based on screening abnormality
| Organ | Follow-up Group | Abnormal result | Appropriate diagnostic test (next test only) | Recommended follow-up (months since diagnostic test due) | Eligible for mFocus (months since diagnostic test due) |
|---|---|---|---|---|---|
| Cervix | High-Risk | Any pap cytology, HPV high risk genotype positive (HPV 16/18 or 45 (MGB only)) * | Colposcopy | 3 | 6 |
| High-Risk | LSIL or ASCUS, HPV+, age 25 years or above | Colposcopy | 3 | 6 | |
| High-Risk | Higher cytology abnormality (ASCH, High grade SIL, HSIL) | Colposcopy | 3 | 6 | |
| High-Risk | LSIL pap, HPV not done, age 25 years or above | Colposcopy | 3 | 6 | |
| High-Risk | AGC pap | Colposcopy | 3 | 6 | |
| High-Risk Endometrial | Endometrial cells, age 50 years or above | Endometrial biopsy | 3 | 6 | |
| Med-Risk | LSIL or ASCUS Pap, HPV +, under age 25 years | Pap with HPV (reflex or cotest) OR Colposcopy | 12 | 15 | |
| Med-Risk | LSIL pap, HPV − | Pap with HPV (reflex or cotest) OR Colposcopy | 12 | 15 | |
| Med-Risk | ASCUS pap, HPV not done OR LSIL pap, HPV not done, under age 25 years | Pap with/ without HPV (reflex or cotest) | 12 | 15 | |
| Med-Risk Cotest | Normal pap, HPV + | Pap with HPV OR Colposcopy | 12 | 15 | |
| Low-Risk | ASCUS pap, HPV− | Pap with or without HPV | 36 | 42 | |
| Breast | High-Risk | Birads 5 | Tissue sample (FNA, biopsy, surgery) | 1 | 3 |
| High-Risk | Birads 4 | Tissue sample (FNA, biopsy, surgery) | 1 | 3 | |
| Low-Risk | Birads 3 | Follow-up imaging | 6 or 12** | 9 or 15** | |
| CRC | High-Risk | Positive FIT | Colonoscopy | 3 | 6 |
| Med-Risk | Colonoscopy requiring 1-year follow-up | Colonoscopy | 12 | 18 | |
| Low-Risk | Colonoscopy requiring 2 or 3-year follow-up | Colonoscopy | 36 | 42 | |
| Low-Risk | Colonoscopy requiring 5-year follow-up | Colonoscopy | 60 | 66 | |
| Lung | High-Risk | Lrads 4b or 4x | Chest CT, Biopsy/ Tissue sample, Thoracoscopy, Bronchoscopy, Appointment in a multi-disciplinary nodule clinic | 1 | 3 |
| High-Risk | Lrads 4a | Chest CT, LDCT, Biopsy/ Tissue sample, Thoracoscopy, Bronchoscopy, Appointment in a multi-disciplinary nodule clinic | 1 | 3 | |
| Low-Risk | Lrads 3 | Chest CT, LDCT, Biopsy/ Tissue sample, Thoracoscopy, Bronchoscopy, Appointment in a multi-disciplinary nodule clinic | 6 | 9 |
NOTES:
*
DH variation: Women < 25 years with NILM or LSIL pathology were recommended to receive follow-up at 12 months and were eligible for mFOCUS at 15 months and could receive Pap with HPV (reflex or cotest) or colposcopy.
**
As specified by radiologist on care team