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. Author manuscript; available in PMC: 2022 Mar 7.
Published in final edited form as: Biosens Bioelectron. 2021 Nov 16;197:113808. doi: 10.1016/j.bios.2021.113808

Fig. 4.

Fig. 4.

Evaluation of sodium sensitivity in the development of sinus arrest in Tg(SCN5A-D1275N). (a) Representative ECG data before and after NaCl treatment with different concentrations. SA appears more frequently in response to the increase of NaCl concentration. (b) The average HR of WT fish (n = 12), showing the slight decrease from 113.4 ± 10.8 BPM without treatment to 102.1 ± 15.0 BPM; the averaged HR of Tg(SCN5A-D1275N) mutant fish (n = 8), showing significant reduction from 122.6 ± 13.7 BPM without treatment to 93.3 ± 11.5 BPM after NaCl treatment. (c) SDNN of WT fish (n = 12) and mutant fish (n = 8), displaying similar variations in HR. (d) QTc values shows slight increase in both wild-type and mutant fish after NaCl treatment.