Table 6.

Brain regions alteration and its potential impact.

Brain regions	Experimental result	Brain function	Anticipated results
Insula	ON < HCs	Involved in consciousness, bodily impulses, and controlling and suppressing natural impulses	Abnormal activation of areas in the insula, diseases such as Alzheimer's disease and epilepsy
Precuneus	ON < HCs	Part of the default model network	Depression and anxiety
Parietal inf	ON>HCs	Part of the default model network, correlated with visual word recognition	Depression and anxiety, reflect compensation of the visual function
Postcentral	ON>HCs	Associated with information processing of tactile stimuli	Compensate the impairment of the sensorimotor dysfunction

ON, optic neuritis; HCs, healthy controls.