FIGURE 4.

Time‐dependent effect on platelet adhesion and fibrin formation on GPVI‐dependent microspots and tissue factor (TF) in protein C or protein S deficiency. Prelabeled blood from controls or patients was flowed over collagen‐I + TF (II.) (A‐C) or GFO‐GER‐(GPO)n + TF (IV) (D‐F); as for Figure 3. Images taken at t = 0–10 min were analyzed for platelet adhesion (P1), phosphatidylserine exposure (P2), and fibrin formation (P7). Shown is per subject group (controls, protein C or protein S deficiency): time dependency of platelet adhesion (A, D), phosphatidylserine exposure (B, E), and fibrin formation (C, F). Italic numbers, p values based on normal distribution (mean ± SE, P vs. controls, 1‐way ANOVA)