Table 3.
Model-generated estimated marginal means of paraoxonase 1 levels in healthy controls and patients with temporal lobe epilepsy and psychosis, depression and anxiety due to temporal lobe epilepsy
|
Variables
|
HC
1
|
TLE
2
|
TLE + PSY
3
|
TLE + DEP
4
|
TLE + ANX
5
|
| CMPAase (U/mL) | 42.1 (1.3)2,3,4,5 | 28.5 (1.6)1 | 24.5 (1.6)1 | 24.8 (1.7)1 | 27.3 (1.7)1 |
| Res CMPAase (z scores) | 1.041 (0.128)2,3,4,5 | -0.196 (0.150)1 | -0.545 (0.163)1 | -0.545 (0.163)1 | -0.375 (0.159)1 |
| Arylesterase (U/mL) | 212.4 (9.0)2,3,4,5 | 156.4 (10.5)1 | 144.2 (10.4)1 | 143.7 (11.4)1 | 137.3 (11.2)1 |
| Res Arylesterase (z scores) | 0.920 (0.140)2,3,4,5 | -0.193 (0.163)1 | -0.425 (0.162)1 | -0.400 (0.177)1 | -0.434 (0.174)1 |
Results of post-hoc comparisons among the five diagnostic groups.
Indicates HC and “1” associated with column figures indicates that this value is different from HC.
Indicates TLE and “2” associated with column figures indicates that this value is different from TLE.
Indicates TLE + PSY and “3” associated with column figures indicates that this value is different from TLE + PSY.
Indicates TLE + DEP and “4” associated with column figures indicates that this value is different from TLE + DEP.
Indicates TLE + ANX and “5” associated with column figures indicates that this value is different from TLE + ANX.
TLE: Temporal lobe epilepsy; TLE: TLE without psychiatric comorbidities; TLE + PSY: Psychotic Disorder due to TLE; TLE + DEP: Mood Disorder due to TLE with depressive features; TLE + ANX: Anxiety Disorder due to TLE; HC: Healthy controls; PON1: Paraoxonase; CMPAase: 4-(chloromethyl)phenyl acetate hydrolysis; Res: Residualized values after regression on PON1 genotype.