Figure 1.

Study design and outputs

The genomic DNA of 143 human embryonic stem cell lines (hESCs) was analyzed by high-density SNP microarray and at the single-nucleotide level by WGS to call structural variants to a resolution of ∼1 kbp, rare sequence variants associated with disease, and common sequence variants to reveal cell line ancestry, relatedness, and polygenic risk score (PRS). An integrated analysis of these data, which are provided as a resource to the field via an interactive data portal, yields insight into hESC biology and facilitates the rational selection of cell lines based on their genetic architecture. See also Table S1 and Figure S1.