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. 2022 Mar 3;29(3):472–486.e7. doi: 10.1016/j.stem.2022.01.011

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Disease risk from common genetic variants

(A–C) Genotyping results at SNPs indicative of (A) blood type (rs8176719 in ABO), (B) resistance to HIV infection (rs333 at CCR5), and (C) risk for Alzheimer’s disease (AD, rs429358 and rs7412 in APOE in shades of orange, and rs75932628 in TREM2 in shades of green). Ref, reference allele; alt, alternate (risk) allele.

(D) Distribution of polygenic risk scores (PRS) for control samples and hESCs reveals “outlier” samples with an SD of two or more.

(E) Heatmap of PRS for each of the 18 analyzed traits for cell lines with at least one “outlier” PRS.

(F) Combined PRS deviation from mean for each of the 18 analyzed traits. See also Table S2 and Figure S2.