Table 3.

Conformational B-cell epitopes from the three-dimensional structure of the human major prion protein

No.	Score	Residues	Reference	Number of Residues	Location on Structure
C1	0.883	Q227, R228, G229, S230, S231, M232, V233, L234, F235	[101]	9	Globular domain and unstructured region
C2	0.811	N100, K101, P102, S103, K104, P105, K106, T107, N108, M109, K110, H111, M112	[101]	13	Flexible tail
C3	0.747	R25, P26, K27, P28, G29, G30, W31, N32, T33, G34, G35, S36, R37, Y38	[101]	14	Flexible tail
C4	0.717	P137, I138, I139, H140, F141, G142, S143, D144, Y145, E146, D147, R148, Y149, R151, E152, N153, Y157, V189, T191, T192, T193, K194, G195, E196, N197, F198, T199, E200, T201, D202, V203, K204	[101]	32	Globular domain
C5	0.708	R164, E168, Y169, S170, N171, Q172, N173, N174, H177	[101]	9	Globular domain
C6	0.708	S222, Q223, A224, Y225	[101]	4	Globular domain
C7	0.669	S236, S237, P238, L242, S245, F246, L247, I248, F249, L250, I251, V252, G253	[101]	13	Unstructured region
C8	0.579	P39, G40, Q41, G42, S43, P44, G45, G46, N47, R48, Y49	[101]	11	Flexible tail
C9	0.55	G55, G56, W57, G58, Q59, P60, H61, G62, G63, G64, W65, G66, Q67, Q75, P76, H77, G78, G79, G80, W81, G82, Q83, P84, H85, G86, W89, G90, Q91, G92, G93, G94, T95, H96, S97, Q98, W99	[101]	36	Octa-repeat & flexible tail