Table 2. LMWTs in rat plasma before and after focal medial cerebral arterial occlusion and global cerebral ischaemia.
| Model | Fraction | Thiols (µmol/l) and redox status (RS, %) | |||||
|---|---|---|---|---|---|---|---|
| Cys | GSH | Hcy | |||||
| * | ** | * | ** | * | ** | ||
| MCAO control | Total | 104 ± 20 | 82 ± 24 | 13.5 ± 4.5 | 10.5 ± 2.2 | 4.1 ± 0.6 | 4.6 ± 1.2 |
| Reduced | 15.3 ± 5.5 | 12.2 ± 4.9 | 3.35 ± 1.2 | 2.5 ± 0.7 | 0.4 ± 0.2 | 0.35 ± 0.17 | |
| RS | 15.7 ± 4.5 | 15 ± 6 | 27 ± 4 | 24 ± 6 | 8.0 ± 2.5 | 8.5 ± 3.5 | |
| MCAO ischaemia | Total | 98 ± 19 | 80 ± 18a | 11.0 ± 2.0 | 13.5 ± 5.0 | 3.3 ± 1.1 | 3.8 ± 0.8 |
| Reduced | 13.2 ± 5.1 | 0.46 ± 0.06b | 4.1 ± 1.5 | 0.21 ± 0.1b | 0.44 ± 0.15 | 0.013 ± 0.006b | |
| RS | 13.3 ± 5.7 | 0.6 ± 0.15b | 37 ± 15 | 0.75 ± 0.15b | 14 ± 4 | 0.36 ± 0.19b | |
| BCAO control | Total | 67 ± 15 | 70 ± 7.0 | 11.2 ± 2.8 | 10.0 ± 3.6 | 3.2 ± 1.1 | 4.0 ± 1.8 |
| Reduced | 8.0 ± 2.4 | 7.3 ± 2.0 | 2.6 ± 0.9 | 2.5 ± 1.1 | 0.38 ± 0.13 | 0.36 ± 0.11 | |
| RS | 12.0 ± 2.7 | 10.5 ± 2.7 | 23 ± 6.8 | 24.4 ± 6.1 | 12 ± 3.5 | 10.7 ± 5.9 | |
| BCAO ischaemia | Total | 64 ± 26 | 47 ± 22 | 11 ± 4 | 14 ± 8 | 3.7 ± 1.2 | 3.2 ± 1.3 |
| Reduced | 8.9 ± 2.6 | 2.1 ± 1.9b | 3.0 ± 1.1 | 1.5 ± 1.3c | 0.4 ± 0.1 | 0.13 ± 0.09b | |
| RS | 15 ± 4 | 4.3 ± 3.3b | 29 ± 9 | 10.4 ± 9.6b | 12 ± 4 | 4.2 ± 3.5b | |
Data are mean ± SD values for 10 animals in each group, expressed in µmol/l.
* Initial level.
** After ischaemia.
Different from the initial level (aP < 0.01, bP < 0.001, cP < 0.05).