Table 5. Activities of phase 1 enzymes [aniline hydroxylase (AnH) and aminopyrine-N-demethylase (AmD)] and phase II enzyme (UDPGT) in the testis of rats treated with NDMA and BA (alone and in combination).
Treatments groups | AnH | AmD | UDPGT |
---|---|---|---|
(μmol/mg protein) | (mmol/mg protein) | ||
Control | 0.398 ± 0.59 | 0.530 ± 0.01 | 0.12 ± 0.02 |
BA | 1.014 ± 098a | 0.485 ± 0.01a | 0.14 ± 0.03a |
NDMA | 1.694 ± 0.86b | 0.840 ± 0.08b | 0.07 ± 0.007b |
BA + NDMA | 0.910 ± 0.21c | 0.612 ± 0.03c | 0.10 ± 0.03c |
Data expressed as mean ± S.D. (n = 6).
aStatistically similar to [BA + NDMA] (P > 0.001).
bStatistically different from control (P < 0.05).
cStatistically different from NDMA (P < 0.05).
BA: betulinic acid; NDMA: N-nitrosodimethylamine.