Table 1: Demographic and clinical characteristics for the total cohort and those who died with COVID-19 in the two time periods.

	Overall cohort			COVID-19 deaths in first period (24th Jan–30th Apr 2020)			COVID-19 deaths in second period (1st May–28th Jul 2020)
	N	%		N	%		N	%
Overall	1,956,760			1192			610
Sex
Male	967,975	49.47		674	56.54		299	49.02
Female	988,785	50.53		518	43.46		311	50.98
Age, years	50.8	18.7		79.4	11.8		81.0	11.1
Age group, years
19-29	318,681	16.29		*			*
30-39	313,802	16.04		*			*
40-49	304,363	15.55		16	1.34		*
50-59	353,539	18.07		61	5.12		28	4.59
60-69	291,042	14.87		132	11.07		49	8.03
70-79	240,840	12.31		305	25.59		136	22.30
80-89	111,631	5.70		429	35.99		250	40.98
≥90	22,862	1.17		242	20.30		138	22.62
Ethnicity
Bangladeshi	7,011	0.36		*			*
Black^	8,312	0.42		*			*
Indian	8,885	0.45		*			*
Mixed	27,582	1.41		*			*
Other^	27,786	1.42		*			*
Pakistani	7,688	0.39		*			0	0.00
White	1,741,527	89.00		1113	93.37		579	94.92
Not recorded	127,969	6.54		52	4.36		19	3.11
Townsend deprivation quintile
1 (most affluent)	335,459	17.14		156	13.09		98	16.07
2	413,486	21.13		221	18.54		129	21.15
3	559,024	28.57		369	30.96		179	29.34
4	453,474	23.17		304	25.50		141	23.11
5 (most deprived)	195,317	9.98		142	11.91		63	10.33
Accommodation
Neither homeless nor care home	1,940,224	99.15		987	82.80		476	78.03
Care home or nursing home	16,536	0.85		205	17.20		134	21.97
Body-mass index, kg/m2
<18.5	21,944	1.12		53	4.45		33	5.41
18.5 to <25	316,569	16.18		277	23.34		161	26.39
25 to <30	375,501	19.19		300	25.17		154	25.25
≥30	403,871	20.64		294	24.66		114	18.69
Not recorded	838,875	42.87		268	22.48		148	24.26
Chronic kidney disease
No Chronic Kidney disease	1,874,451	95.79		869	72.90		412	67.54
Stage 3	72,669	3.71		252	21.14		165	27.05
Stage 4	3,928	0.20		30	2.52		20	3.28
Stage 5	5,712	0.29		41	3.44		13	2.13
Learning disability
No learning disability	1,928,040	98.53		1163	97.57		587	96.23
Learning disability	28,486	1.46		29	2.43		23	3.77
Down Syndrome	234	0.01		0	0.00		0	0.00
Chemotherapy								0.00
No chemotherapy in past 12-months	1,949,761	99.64		1167	97.90		597	97.87
Chemotherapy in past 12-months	6,999	0.36		25	2.10		13	2.13
Cancer and immunosuppression
Blood cancer	10,547	0.54		38	3.19		14	2.30
Respiratory cancer	5,691	0.29		20	1.68		10	1.64
Radiotherapy in past 6-months	1,827	0.09		*			*
Bone marrow transplant in past 6-months	56	0.00		0	0		0	0.00
Solid organ transplant	806	0.04		*			*
Prescribed immunosuppressant medication by GP	2,884	0.15		*			*
Prescribed leukotriene or LABA	38,658	1.98		59	4.95		42	6.89
Prescribed regular prednisolone	15,819	0.81		61	5.12		28	4.59
Other comorbidities
Diabetes	161,227	8.24		359	30.12		178	29.18
COPD	66,937	3.42		209	17.53		100	16.39
Asthma	290,490	14.85		186	15.60		109	17.87
Rare pulmonary diseases	9,471	0.48		26	2.18		12	1.97
Pulmonary hypertension or pulmonary fibrosis	3,741	0.19		17	1.43		14	2.30
Coronary heart disease	89,686	4.58		239	20.05		137	22.46
Stroke	55,336	2.83		233	19.55		121	19.84
Atrial fibrillation	62,712	3.20		253	21.22		140	22.95
Congestive cardiac failure	30,937	1.58		151	12.67		99	16.23
Venous thromboembolism	43,708	2.23		111	9.31		54	8.85
Peripheral vascular disease	18,639	0.95		77	6.46		36	5.90
Congenital heart disease	17,071	0.87		30	2.52		12	1.97
Dementia	18,840	0.96		304	25.50		160	26.23
Parkinson’s disease	5,717	0.29		40	3.36		32	5.25
Epilepsy	26,112	1.33		31	2.60		19	3.11
Rare neurological conditions	5,789	0.30		*			*
Cerebral palsy	1,318	0.07		0	0.00		0	0.00
Severe mental illness	282,709	14.45		209	17.53		109	17.87
Osteoporotic fracture	73,679	3.77		154	12.92		96	15.74
Rheumatoid arthritis or SLE	22,485	1.15		35	2.94		16	2.62
Cirrhosis of the liver	7,210	0.37		17	1.43		*
Sickle cell disease	1,094	0.06		0	0		0	0.00

Data are n (%) or mean (SD). * represents values which have been suppressed due to small numbers <10. ^{^}represents collapsing of categories to suppress small numbers.