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. Author manuscript; available in PMC: 2022 Mar 7.
Published in final edited form as: Nat Chem Biol. 2021 Apr 29;17(8):856–864. doi: 10.1038/s41589-021-00785-8

Extended Data Fig. 5. Effects of ABD957 treatment on N-Ras turnover in OCI-AML3 cells.

Extended Data Fig. 5

a, Degradation and synthesis curves for N-Ras in OCI-AML3 cells treated with DMSO or ABD957 (500 nM). Each dot represents a peptide spectrum match (PSM) from one of three biological replicates. OCI-AML3 cells grown in light SILAC media were pelleted and resuspended in heavy SILAC media containing DMSO or ABD957 and harvested at the indicated times. Also see Supplementary Dataset 4.