Table 3. The binding affinity of the bromodomains for NS5 and L10a.
| Bromodomain | Binding affinity (K d) (µM) |
|---|---|
| NS5 | |
| BD1, wild type | 2.0 |
| BD1, W97A | 8.3 |
| BD1, N156A | 75.6 |
| BD1, I162A | 11.6 |
| BD2, wild type | 43.5 |
| L10a | |
| BD2, wild type | 54.8 |
| BD2, N429A | 106.9 |
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