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. 2022 Feb 21;78(Pt 3):363–378. doi: 10.1107/S2059798322000948

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© Fornasier et al. 2022

This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.

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SARS-CoV-2 M^pro architecture, free form (PDB entry 6y2e). (a) Dimeric assembly of the protease with the main structural features discussed in the text highlighted. Protomer A is in blue-based colors and protomer B is in yellow/red-based colors. The two oxyanion loops and the two catalytic cysteines 145 are shown in green. (b) Comparison between different oxyanion-loop conformations of M^pro: active in SARS-CoV-2 M^pro (PDB entry 6y2e) in pink, collapsed-inactive in SARS-CoV M^pro (PDB entry 1uj1 chain B) in magenta and new-inactive in SARS-CoV-2 M^pro (this work) in green.