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Comparison between new-inactive (green) and active (light magenta) Mpro. In the new structure the side chain of His163 rotates away to avoid steric clashes with the oxyanion loop: in the active conformation (PDB entry 6y2e) the His163 side chain would be 1.2 Å from the new position of Gly143 CO. Note also the movement of His172.
