Figure 6.
Displacements at the intra-protomer interface. New-inactive Mpro is in green and active Mpro is in magenta. (a) The new oxyanion loop of one protomer pushes away residues 1′–3′ of the other protomer; however, the key salt bridge between Arg4′ and Glu290, which is important for dimer stabilization, is conserved. (b) Overall superposition of active and new-inactive Mpro shows that besides those in the oxyanion loop (red ellipsoid), major differences are located in the N-finger and in the C-terminal tail, which is not visible in new-inactive Mpro.