Figure 2.

A, Data were obtained from the European Committee on Antimicrobial Susceptibility Testing (EUCAST) database (https://mic.eucast.org/search/, accessed 2 December 2020). B, Data were adapted from Ekkelenkamp et al [28]. Epidemiological cutoff (ECOFF), as determined in non–cystic fibrosis (CF) isolates = 2 mg/L; Susceptible with standard dose (S) ≤2 mg/L; Resistant (R) >2 mg/L. Comparison of A and B shows how the distribution of the minimum inhibitory concentrations (MICs) has been skewed toward higher MICs for the Pseudomonas aeruginosa strains of persons with CF, likely due to adaptation of these strains to antibiotic exposure; in B, it is therefore not possible to establish a clear ECOFF.