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. 2021 Aug 17;53(2):128–137. doi: 10.1093/labmed/lmab068

Figure 3.

Figure 3.

Meropenem Inhibits ESBL CCO Hydrolysis: (A) EICs of the protonated molecular ions of ceftriaxone, cefazolin, oxacillin, meropenem and IS are shown after incubation with a sample not containing extended spectrum beta lactamase (-ESBL) expressing pathogen. Exact m/z of the protonated molecular ion for each compound is indicated. (B) EICs of the protonated molecular ions of ceftriaxone, cefazolin, oxacillin, meropenem, and IS are shown after incubation with a sample containing an ESBL containing specimen (-ESBL). Expected retention times of the protonated molecular ions for each compound are indicated to illustrate the loss of a peak. % ion intensity (indicated at top left of each EIC) is plotted on the Y-axis and Time (min) is plotted on the X-axis. (C) Boxplots plotted on a log scale of individual median ratios of CCO and meropenem/IS after incubation with: Control DFU –drug free urine (n = 3) or ESBL containing urine specimens (n = 10).