Table. 5.

Pathway analysis of the middle ear effusion exosome proteomic dataset

Top canonical pathways	P value	Overlap %
Glycolysis	2.39E−06	12
Hypoxia signaling	4.41E−05	4.6
Remodeling of epithelial
junctions	5.05E−05	4.4
Actin cytoskeleton signaling	7.38E−05	1.9
Upstream regulators	P value
HIF1α	3.35E−08
LPS	7.93E−08
Diseases and disorders	P value	Molecules
Inflammatory response	5.32E−03 to 1.62E−06	15
Molecular and cellular functions	P value	Molecules
Cellular movement	6.07E−03 to 3.24E−12	18
Cellular function and maintenance	5.32E−03 to 3.52E−08	17
Cell-to-cell signaling and interaction	6.38E−03 to 2.12E−07	13
Cell death and survival	6.38E−03 to 3.16E−07	17
Cellular assembly and organization	4.95E−03 to 1.37E−06	11

LPS, lipopolysaccharide.