TABLE 1.
Baseline Demographics and HIV-Related Characteristics of Group
| HIV+ Heroin+, n = 19 |
HIV+ Heroin−, n = 19 |
HIV− Heroin+, n = 38 |
HIV− Heroin−, n = 24 |
P, Overall* |
P, HIV+ vs HIV−* |
P, Heroin+ vs Heroin−* |
|
| Age, yrs | 47 (32.9, 54.9) | 46.5 (32.4, 53.8) | 37.5 (34.1, 50.5) | 44.3 (32.6, 52.3) | 0.61 | 0.28 | 0.56 |
| Male | 14 (74) | 15 (79) | 27 (71) | 19 (79) | 0.88 | 0.81 | 0.41 |
| Race/ethnicity | <0.0001 | <0.001 | <0.001 | ||||
| White, non-Hispanic | 10 (53) | 2 (11) | 26 (68) | 17 (71) | |||
| Black, non-Hispanic | 2 (11) | 15 (79) | 5 (13) | 5 (21) | |||
| Asian, non-Hispanic | 0 (0) | 1 (5) | 2 (5) | 1 (4) | |||
| Hispanic | 7 (37) | 1 (5) | 5 (13) | 1 (4) | |||
| Current smoker | 19 (100) | 11 (58) | 37 (97) | 7 (29) | <0.0001 | 0.38 | <0.0001 |
| BMI, kg/m2 | 23.6 (21.6, 25.2) | 26 (23.5, 29.8) | 25.8 (22.9, 28.3) | 26.6 (22.9, 29.7) | 0.02 | 0.12 | 0.06 |
| Trunk fat, g | 6839 (5561, 9452) | 11,576 (8460, 15,969) | 9126 (6632, 14,819) | 12,136 (7233, 14,623) | <0.01 | 0.17 | <0.01 |
| Hepatitis C | 11 (58) | 0 (0) | 21 (55) | 0 (0) | <0.0001 | 0.61 | <0.0001 |
| HIV duration, yrs | 11.8 (2.3, 18.9) | 13.2 (8.1, 16.7) | — | — | — | — | 0.82 |
| ART duration, yrs | 4.5 (1.8, 9.4) | 8.7 (6.8, 13.8) | — | — | — | — | 0.02 |
| On ISTI | 10 (53) | 13 (68) | — | — | — | — | 0.32 |
| On PI | 6 (32) | 3 (16) | — | — | — | — | 0.25 |
| On NNRTI | 1 (5) | 7 (37) | — | — | — | — | 0.02 |
| CD4+, cells/mm3 | 562 (276, 799) | 767 (623, 1035) | — | — | — | — | 0.02 |
| Nadir CD4+, cells/mm3 | 201 (42, 301) | 212 (110, 280) | — | — | — | — | 0.83 |
| HIV-1 RNA <200 copies/mL | 16 (84) | 19 (100) | — | — | — | — | 0.07 |
| Heroin route | — | <0.0001 | — | ||||
| Intravenous | 14 (74) | — | 38 (100) | — | |||
| Intranasal | 5 (26) | — | 0 (0) | — | |||
| Amount of heroin per week, in grams | 7 (2, 7) | 6 (3.5, 7) | 0.92 | ||||
| Current substance use | |||||||
| Cannabis | 10 (53) | 14 (73) | 22 (58) | 6 (25) | 0.01 | 0.08 | 0.34 |
| Cocaine | 9 (47) | 1 (5) | 19 (50) | 2 (8) | <0.001 | 0.43 | <0.0001 |
| Methamphetamine | 3 (16) | 0 (0) | 4 (11) | 0 (0) | 0.16 | >0.99 | 0.04 |
Values shown are median (interquartile range) and frequency (column percentage).
*
The Kruskal–Wallis or Pearson exact and χ2 tests for comparisons of more than 2 groups and the Wilcoxon rank sum or χ2 test for comparison between 2 groups.
BMI, body mass index; ISTI, integrase strand transfer inhibitor; PI, protease inhibitor; NNRTI, nonnucleoside reverse transcriptase inhibitor.