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. 2022 Mar 7;130(3):037003. doi: 10.1289/EHP9745

Figure 1.

Figure 1 is a flowchart titled Association study having three steps. Step 1: Participant recruitment with urine sample leads to First trimester exposome determination, including inorganic exposome with an icon of a periodic table, I C P-M S with icons of a server, identification card, and monitor, organic exposome with an icon of four graphs, and U H P L C-Q E-H R M S, including icons of a server, printer, and monitor; and Third trimester metabolome determination, including U H P L C-Q E-H R M S, including icons of a server, printer, and monitor; Metabolome, including four graphs; and chemical reaction between exposome and metabolome. Step 2: Step 1 leads to Association based on statistical analysis to find: Environmentally Determined Metabotypes during Pregnancy, with significance mining including literature searching with desktop system icon and bioinformatics analysis with network icon leads to Literature searching and bioinformatics analysis to use Environmentally Determined Metabotypes to explain: Exposome-Metabolome-Outcomes, including exposome with an Earth icon and Metabolome with an icon of a pregnant woman, which leads to Outcomes. Step 3: Step 2 leads to Outcomes, including Gestational age, Birth weight, Fat deposition, Neurodevelopment abnormality, Immunological disorder, and Hypertension.

Study Design. Note: ICP-MS, inductively coupled plasma mass spectrometry; UHPLC-QE-HRMS, ultra-high performance liquid chromatography–Q Exactive hybrid quadrupole-orbitrap high resolution mass spectrometry.