TABLE 4.
Synthetic and semisynthetic antifungal peptides
| Peptide | Structure | Mode of action | Typical target organism | In vitro MIC (μg/ml) |
|---|---|---|---|---|
| Cilofungin (LY121019) | Lipopeptide | Glucan synthesis | C. albicans | 0.62 |
| D4E1 | Linear peptide | Lysis (?) | A. flavus | 26.25 |
| L731,373 | Lipopeptide | Glucan synthesis | C. albicans | ≤0.06 |
| L733,560 | Lipopeptide | Glucan synthesis | C. albicans | 0.06 |
| L743,872 (MK-0991) | Lipopeptide | Glucan synthesis | A. flavus | 0.09–3.12 |
| L773,560 | Lipopeptide | Glucan synthesis | C. albicans | 0.5 |
| LY303366 | Lipopeptide | Glucan synthesis | Candida krusei | 0.5 |