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. 2022 Mar 7;11:e72416. doi: 10.7554/eLife.72416

Figure 1. Clustered protocadherin (cPcdh) domain organization and extracellular interactions.

Figure 1.

(A) Schematic depicting the domain organization of cPcdhs. EC, extracellular cadherin domain; TM, transmembrane domain; ECD, ectodomain; ICD, intracellular domain. (B) Schematic of two cPcdhs interacting via the EC1–4 trans interface. (C) Schematic of two cPcdhs interacting via the EC5–6/EC6 cis interface. (D) Schematic depiction of the cis/trans cPcdh zipper comprising multiple cPcdh isoforms (various colors) engaged in homophilic trans interactions and promiscuous cis interactions as required for the proposed ‘isoform-mismatch chain-termination model’ of cPcdh-mediated neuronal self-recognition and self-avoidance.