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. Author manuscript; available in PMC: 2022 Mar 7.
Published in final edited form as: J Med Chem. 2019 Feb 15;62(4):1989–1998. doi: 10.1021/acs.jmedchem.8b01541

Figure 5.

Figure 5.

Circadian behavior of longdaysin- and NCC007-treated mice. Mice were treated with compounds and their circadian behavior was recorded by infrared sensor under constant dark condition. (A) HBSS, 1 mM longdaysin, 5 mM longdaysin, and 5 mM NCC007 were sequentially infused into mouse brain. (B) HBSS, 3 mM longdaysin, 15 mM longdaysin, and 15 mM NCC007 were sequentially infused. (C) DMSO infusion as the negative control. The number in parentheses indicates the number of mice. ***p < 0.001, **p < 0.01 against the DMSO control by two-way analysis of variance, followed by a Tukey’s multiple comparisons test.