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Effect of metabolic inhibitors and membrane stimuli on the uptake of moxifloxacin by human PMN
| Conditiona | C/E ratio |
|---|---|
| Viable cells at 37°C (control) | 10.9 ± 1.0 |
| Metabolic inhibitor | |
| Sodium fluoride | 6.8 ± 1.3b |
| Sodium cyanide | 5.8 ± 0.7b |
| CCCP | 5.7 ± 1.3b |
| 2,4-Dinitrophenol | 9.9 ± 1.0 |
| Stimulus | |
| PMA | 11.0 ± 0.9 |
| S. aureus | 9.1 ± 0.3 |
Experiments were carried out for 20 min at an extracellular concentration of 5 mg/liter with PMN from five subjects.
P ≤ 0.05 compared to viable cells at 37°C.
