Table 1.
The Demographic and Key Baseline Characteristics of the Healthy Volunteers
| Single Dose Part | Multiple Dose Part | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Pooled Placebo N=12 | 7 μg N=6 | 38 μg N=6 | 187 μg N=6 | 624 μg N=5 | 1248 μg N=6 | 1872μg N=6 | Pooled Placebo N=9 | 312 μg N=6 | 1248 μg N=5 | 1872 μg N=6 | |
| Age in years, Mean (range) | 28 (20–37) | 30 (21–43) | 32 (22–41) | 31 (21–42) | 35 (27–45) | 30 (20–40) | 30 (20–44) | 27 (20–33) | 31 (23–42) | 36 (31–44) | 34 (27–40) |
| Height in cm Mean (SD) | 178.1 (5.6) | 177.0 (5.5) | 175.8 (8.9) | 173.3 (7.4) | 177.6 (3.6) | 175.3 (5.2) | 176.8 (8.3) | 179.4 (6.6) | 175.4 (6.8) | 171.2 (9.5) | 176.2 (4.4) |
| Weight in kg Mean (SD) | 82.1 (11.0) | 77.8 (8.7) | 73.7 (12.4) | 74.2 (7.5) | 80.9 (6.7) | 73.1 (7.0) | 74.5 (4.5) | 77.6 (13.1) | 80.2 (5.7) | 72.5 (13.4) | 80.1 (10.6) |
| BMI in kg/m2 Mean (SD) | 25.83 (2.81) | 24.94 (3.49) | 23.67 (2.32) | 24.73 (2.48) | 25.60 (1.49) | 23.82 (2.62) | 23.90 (1.43) | 23.96 (2.59) | 26.05 (1.25) | 24.63 (3.35) | 25.74 (2.75) |
| Race (n [%]) | |||||||||||
| Asian | 1 (8.3) | 0 (0.0) | 1 (16.7) | 1 (16.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (22.2) | 1 (16.7) | 0 (0.0) | 0 (0.0) |
| Black or African American | 1 (8.3) | 3 (50.0) | 1 (16.7) | 1 (16.7) | 0 (0.0) | 0 (0.0) | 1 (16.7) | 3 (33.3) | 1 (16.7) | 0 (0.0) | 2 (33.3) |
| White | 10 (83.3) | 3 (50.0) | 4 (66.7) | 3 (50.0) | 5 (100.0) | 6 (100.0) | 5 (83.3) | 4 (44.4) | 4 (66.7) | 5 (100.0) | 4 (66.7) |
| Other | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (16.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |